Being able to diagnose different subtypes of breast cancer has led to highly effective personalised treatments. Your mother. Your sister. Your best friend. You love these women unconditionally because of all the little things that make them who they are.
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Second Cancers After Breast Cancer
Robert A. Wolff | MD Anderson Cancer Center
By Cesar A. A deeper understanding of biology has allowed significant advances in the treatment of breast cancer. In the early-stage setting, standard pathology measures can help identify which subset of patients with hormone receptor—positive breast cancers are more likely to experience benefit from adjuvant chemotherapy, and major efforts have focused on improving the accuracy of predictive biomarker testing. In recent years, several molecular assays assessing tumor biology became commercially available in the United States and Europe, including Prosigna, MammaPrint, and Oncotype DX. Most have been clinically validated for their prognostic utility, and some predict outcome in the presence or absence of adjuvant chemotherapy. While these assays examine various genes related to breast cancer, they are largely associated with measures of proliferation. Timing is also a factor, as a decision to order a molecular assay may delay final clinical decision-making; however, automatically ordering such tests for every single newly diagnosed breast cancer case may not always be helpful or required.
Breast Cancer Advisor: Wolff
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As a member of the Breast Cancer Program, the research efforts of Dr. Wolff have focused on improving the treatment options of patients with breast cancer, improving accrual to clinical trials, the implementation of research findings in clinical practice, and improving quality of care. He is also interested in the development of prognostic and predictive biomarkers tissue, blood, and imaging , and collaborates with Johns Hopkins investigators in MRI Radiology in the development of new magnetic resonance imaging technologies as predictive tools for early response assessment in patients with operable breast cancer and with investigators in the Breast Cancer Program in the development of methylation marker tools for use in breast cancer. In , Dr. Wolff is also interested in survivorship, needs assessments, and educational needs of breast cancer patients.